Drexel University College of Medicine

2012 International Symposium
Institute for Molecular Medicine and Infectious Disease

June 19-21, 2012

Day One ¦ Day Two ¦ Day Three ¦ Show All
  • Agenda
  • June 19

    Registration and Continental Breakfast - 7:30 - 9:00

    Introductory Remarks - 9:00 - 9:10

    Session 1 - 9:10 - 11:00
    Co-Chairs: Julio Martin-Garcia, Barry Waterhouse

    HIV/AIDS, brain impairment, and neuroprotection

    Schedule

    9:10 - 9:40

    Avindra Nath, M.D., Senior Investigator Director, Section of Infections of the Nervous System
    National Institutes of Health, Bethesda, MD
    “HIV Reservoir in the brain: Can it be cured?”

    9:45 - 10:05

    Dennis Kolson, M.D., Ph.D., Professor of Neurology
    University of Pennsylvania School of Medicine, Philadelphia, PA
    "Human immunodeficiency virus-mediated neurodegeneration: therapeutic targeting of the macrophage anti-oxidant response"

    10:10 - 10:30

    Timothy J. Cunningham, Ph.D., Professor of Neuroscience and Anatomy
    Drexel University College of Medicine, Philadelphia, PA
    "Inflammation and Neuron Death: Therapeutic Studies with Secreted Phospholipase A2 Inhibitors"

    10:35 - 10:55

    Olimpia Meucci, M.D., Ph.D., Professor of Pharmacology and Physiology
    Drexel University College of Medicine, Philadelphia, PA
    “Neuroprotective function of the chemokine CXCL12 and its potential role in HIV associated neurocognitive disorders”

    Session 2 - 11:00 - 12:00
    Introduction: Kenny Simansky, Noshin Kathuria

    Drexel Prize in Translational Research

    Schedule

    11:00 - 12:00 noon

    Paul Offit, M.D., Chief, Division of Infectious Diseases, Professor of Pediatrics;
    Director, Vaccine Education Center, Children's Hospital of Philadelphia, Philadelphia, PA
    "The Rotavirus Vaccine: From Bench to Bedside."

    Lunch and Poster Session 1 - 12:00 - 1:30
    18th floor, New College Building

    Session 3 - 1:30 - 3:00
    Co-Chairs: Heather Painter, Akhil Vaidya

    Molecular mechanisms of malarial disease

    Schedule

    1:30 - 1:55

    Kiaran Kirk, Ph.D., Professor, Research School of Biology
    The Australian National University, Canberra, Australia
    “A sodium pump as an antimalarial drug target”

    2:00 - 2:20

    Lawrence W. Bergman, Ph.D., Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    "A New Myosin Motor in Malaria Parasites"

    2:25 - 2:40

    Michael Mather, Ph.D., Research Assistant Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “The unusual ATP synthase complexes of a ciliate and a malaria parasite: evolution of a central player in bioenergetics”

    2:45 - 2:55

    Elamaran Melbalan, M.S., Graduate Student, Microbiology and Immunology Graduate Program
    Drexel University College of Medicine, Philadelphia, PA
    “Trafficking in Plasmodium yoelii: export of proteins from the intracellular malarial parasite to the host reticulocyte membrane”

    Session 4 - 3:00 - 4:30
    Co-Chairs: Garth Erhlich, Richard Rest

    Pathogenic mechanisms of bacterial disease

    Schedule

    3:00 - 3:25

    David Mosser, Ph.D., Professor of Cell Biology and Molecular Genetics
    University of Maryland, College Park, MD
    “The role of macrophages in promoting and preventing inflammatory diseases”

    3:30 - 3:50

    Jacob Russell, Ph.D., Assistant Professor of Biology
    Drexel University, Philadelphia, PA
    "Exploring the microbiomes of insect guts: effects of diet and relatedness on the composition of symbiotic communities"

    3:55 - 4:10

    Shira Ninio, Ph.D., Assistant Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “Novel virulence determinants of Legionella pneumophila identified using an injected bacterial protein”

    4:15 - 4:25

    Jeffrey P. Holt, Graduate Student in Biological Sciences, College of Arts and Sciences
    Drexel University, Philadelphia, PA
    “Identification of a phase-variable restriction barrier of Campylobacter jejuni”

    Break - 4:30 - 5:00

    Session 5 - 5:00 - 6:35
    Co-Chairs: Lawrence Bergman, Michele Kutzler

    Control of microbial disease

    Schedule

    5:00 - 5:25

    Michael K. Riscoe, Ph.D., Professor of Microbiology and Director, Experimental Chemotherapy Laboratory
    Oregon Health Sciences University and Portland VA medical Center, Portland, OR
    "Revisiting Historical Leads for Clues to the Future of Antimalarial Drug Design"

    5:30 - 5:50

    Purnima Bhanot, Ph.D., Assistant Professor of Microbiology and Molecular Genetics
    UMDNJ – New Jersey Medical School, Newark, NJ
    “Preventing malaria infection by targeting Plasmodium pre-erythrocytic stages”

    5:55 - 6:15

    Akhil Vaidya, Ph.D., Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “Molecular Pathways Targeted by Novel Antimalarial Drugs”

    6:20 - 6:30

    Scott Baliban, Graduate Student, Microbiology and Immunology Graduate Program
    Drexel University College of Medicine, Philadelphia, PA
    "Toxin-based DNA vaccination for the prevention of Clostridium difficile-associated disease"

  • June 20

    Continental Breakfast - 8:00 - 9:00

    Session 6 - 9:00 - 11:00
    Co-Chairs: Olimpia Meucci, Jay Rappaport

    HIV/AIDS and substance abuse

    Schedule

    9:00 - 9:25

    Sabita Roy, Ph.D., Professor of Surgery
    Director, Division of Infection, Inflammation and Vascular Biology
    University of Minnesota, Minneapolis, MN
    "Morphine induction of Toll like receptors on microgial cells potentiates HIV-1 TAT induced neuropathogenesis in a pneumococcal pneumoniae co-infection model"

    9:35 - 10:00

    Ellen Unterwald, Ph.D., Professor of Pharmacology
    Director, Center for Substance Abuse Research
    Temple University School of Medicine, Philadelphia, PA
    "Modulation of cocaine-induced behaviors and neurotransmission by the chemokine CXCL12"

    10:05 - 10:25

    Tracy Fischer-Smith, Ph.D., Assistant Professor of Neuroscience
    Temple University School of Medicine, Philadelphia, PA
    “Morphine and SIV mediated neuroimmune modulation in rhesus macaques”

    10:30 - 10:40

    Nizari Parikh, Graduate Student, Molecular and Cellular Biology and Genetics Program
    Drexel University College of Medicine, Philadelphia, PA
    “Cocaine alters the immunomodulatory profile in HIV-1-infected patients”

    10:45 - 10:55

    Jonathan Pitcher, MD/PHD Student, Microbiology and Immunology Graduate Program
    Drexel University College of Medicine, Philadelphia, PA
    “Morphine-induced alteration of ferritin heavy chain and disruption of the chemokine receptor CXCR4 in neurons"

    Session 7 - 11:00 - 12:00
    Introduction: Richard Rest, Jennifer Kress-Bennet

    Drexel Prize in Infectious Disease

    Schedule

    11:00 - 12:00

    John Mekalanos, Ph.D., Professor and Chair, Department of Microbiology and Immunology
    Harvard Medical School, Boston, MA
    "A View to a Kill: Molecular and Cellular Interactions in Pathogenesis"

    Lunch and Poster Session 2 - 12:00 - 1:30
    18th floor, New College Building

    Session 8 - 1:30 - 3:00
    Co-Chair: Stephen Jennings, Peter Katsikis

    Molecular mechanisms of inflammation

    Schedule

    1:30 - 1:55

    Thirumala-Devi Kanneganti, Ph.D., Associate Member, Department of Immunology
    St. Jude Children’s Research Hospital, Memphis, TN
    “Regulators of Inflammatory Responses”

    2:00 - 2:20

    Carol M. Artlett, Ph.D., Associate Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “Inflammasome activation in fibrotic disease”

    2:25 - 2:40

    Uri Hershberg, Ph.D., Assistant Professor, School of Biomedical Engineering, Science and Health Systems
    Drexel University, Philadelphia, PA
    “Detecting inflammatory diversification of the B cell repertoire at the level of a single clone and as a whole”

    2:45 - 2:55

    Alina Boesteanu, Ph.D., Research Assistant Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “The role of PI3K p110delta isoform in reducing morbidity and mortality in Influenza virus infected mice”

    Session 9 - 3:00 - 4:30
    Co-Chairs: Michael Bouchard, Laura Steel

    Pathogenic mechanisms of hepatitis B/C

    Schedule

    3:00 - 3:25

    David B. Weiner, Ph.D., Professor of Pathology and Laboratory Medicine
    University of Pennsylvania School of Medicine, Philadelphia, PA
    “Synthetic DNA Vaccine Approaches for Difficult Pathogens”

    3:30 - 3:50

    Anand Mehta, D. Phil, Associate Professor of Microbiology and Immunology
    Drexel University College of Medicine, Doylestown, PA
    "Human hepatitis B virus utilizes a genetic approach to limit antigen presentation"

    3:55 - 4:10

    Sonia Navas-Martin, Ph.D., Assistant Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “Hepatitis C Virus and Macrophages”

    4:15 - 4:25

    Siddhartha Rawat, Graduate Student, Molecular & Cell Biology & Genetics Program
    Drexel University College of Medicine, Philadelphia, PA
    “Akt and NF-kB pathways differentially regulate HBV replication”

    Break - 4:30 - 5:00

    Session 10 - 5:00 - 6:40
    Co-Chairs: Jennifer Gordon, Brian Wigdahl

    Viral oncogenic disease

    Schedule

    5:00 - 5:25

    Kamel Khalili, Ph.D., Laura H. Carnell Professor of Neuroscience
    Chair, Department of Neuroscience and Director, Center for Neurovirology
    Temple University School of Medicine, Philadelphia, PA

    5:30 - 5:55

    James C. Alwine, Ph.D., Professor of Cancer Biology
    University of Pennsylvania School of Medicine, Philadelphia, PA
    “Dealing with stress: The maintenance of mTOR kinase activity during human cytomegalovirus infection”

    6:00 - 6:15

    Michael Bouchard, Ph.D., Associate Professor of Biochemistry and Molecular Biology
    Drexel University College of Medicine, Philadelphia, PA
    “Hepatitis B virus regulation of calcium signaling; a potential factor in the development of hepatitis B virus associated liver cancer”

    6:20 - 6:35

    Pooja Jain, Ph.D., Associate Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    "The dynamic interaction of Tax, RNAi, and chromatin remodelers determines the fate of HTLV-1 infection"

  • June 21

    Continental Breakfast - 8:00 - 9:00

    Session 11 - 9:00 - 11:00
    Co-Chairs: Anand Mehta, Ying-Hsiu Su

    Impact of aging on HIV disease

    Schedule

    9:00 - 9:25

    Richard G. Pestell, M.D., Ph.D., Professor and Chairman, Department of Cancer Biology;
    Director, Kimmel Cancer Center at Jefferson, Thomas Jefferson University, Jefferson Medical College, Philadelphia, PA
    “Novel Roles of Cyclins in Cancer”

    9:30 - 9:50

    Lynn Pulliam, Ph.D., Professor of Laboratory Medicine and Medicine, University of California, San Francisco; Chief, Microbiology, Veterans Affairs Medical Center, San Francisco, CA
    “Search for predictive biomarkers of neurocognitive impairment in HIV and/or HCV infections”

    9:55 - 10:15

    Avi Ma’ayan, Ph.D., Assistant Professor of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Icahn Medicine Institute, New York, NY
    "Data Mining Strategies in Systems Biology and Systems Pharmacology"

    10:20 - 10:35

    Peter Clark, Ph.D., Postdoctoral Fellow, Computational Medicine Center
    Thomas Jefferson University, Philadelphia, PA
    “Comprehensive Transcriptome Profiling of Colorectal Cancer Dukes Staging Reveals miRNA Interactions and Phenotype Markers”

    10:40 - 10:55

    Surbhi Jain, Ph.D., Postdoctoral Fellow, Department of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “Epigenetic Modifications Of The Viral And Host DNA In HCC: A Biomarker Perspective”

    Session 12 - 11:00 - 12:00
    Introduction: Peter Katsikis, Donald Gracias

    Drexel Prize in Immunology

    Schedule

    11:00 - 12:00

    Bruce Beutler, M.D., 2011 Nobel Prize in Physiology or Medicine Recipient, Professor and Director, Center for the Genetics of Host Defense, UT Southwestern Medical Center, Dallas, TX
    “How mammals sense infection"

    Lunch and Poster Session 3 - 12:00 - 1:30
    18th floor, New College Building

    Session 13 - 1:30 - 3:00
    Co-Chairs: Irwin Chaiken, Fred Krebs

    Treatment & prevention of HIV disease

    Schedule

    1:30 - 1:55

    Phalguni Gupta, Ph.D., Professor and Assistant Chair of Infectious Disease and Microbiology
    University of Pittsburgh, Pittsburgh, PA
    “Development of a Ring Formulated microbicide against HIV”

    2:00 - 2:20

    Peter Katsikis, M.D., Ph.D., Professor of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    "Targeting HIV-1 and TLR7/9 as a microbicide strategy"

    2:25 - 2:40

    Michele Kutzler, Ph.D., Assistant Professor of Medicine, Division of Infectious Diseases and HIV Medicine
    Drexel University College of Medicine, Philadelphia, PA
    “Improving prophylactic HIV-1 DNA vaccines through optimization, deliver and immunoadjuvants: from bench to bedside"

    2:45 - 2:55

    Rosemary Bastian, Graduate Student, Biomedical Engineering Program
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA
    "HIV-1 Inactivation and Virolysis by gp120 Targeting Before Host Cell Exposure"

    Session 14 - 3:00 - 4:35
    Co-Chairs: Andres Kriete, Vanessa Pirrone

    Biomarkers of human infectious disease and cancer

    Schedule

    3:00 - 3:30

    Rita Effros, Ph.D., Professor of Pathology and Laboratory Medicine
    University of California, Los Angeles, David Geffen School of Medicine at UCLA, Los Angeles, CA
    “HIV/AIDS: accelerated aging of the adaptive immune system”

    3:35 - 4:00

    Donna Murasko, Ph.D., Professor of Biology
    Dean, College of Arts and Sciences, Drexel University, Philadelphia, PA
    “Changes in Immune Response with Age: Nature or Nurture?”

    4:05 - 4:30

    Claudio Torres, Ph.D., Research Assistant Professor of Pathology and Laboratory Medicine
    Drexel University College of Medicine, Philadelphia, PA
    “Astrocyte Senescence and neurodegenerative disease: implications for HIV-associated neurocognitive disorder“

    Break - 4:35 - 5:00

    Session 15 - 5:00 - 6:30
    Co-Chairs: Jane Clifford, Brian Moldover

    Molecular genetics and infectious disease

    Schedule

    5:00 - 5:25

    Garth D. Ehrlich, Ph.D., Executive Director
    Center for Genomic Sciences, Allegheny-Singer Research Institute, Pittsburgh, PA

    5:30 - 5:50

    Aydin Tozeren, Ph.D., Distinguished Professor and Director, Center for Integrated Bioinformatics
    School of Biomedical Engineering, Science & Health Systems, Drexel University, Philadelphia, PA
    “Bioinformatics as a tool for deciphering the grammar of crosstalk between host and pathogen”

    5:55 - 6:10

    Michael Nonnemacher, Ph.D., Assistant Professor, Department of Microbiology and Immunology
    Drexel University College of Medicine, Philadelphia, PA
    “HIV-1 LTR polymorphisms associated with alterations in clinical course and neurologic disease”

    6:15 - 6:25

    Jennifer Kress-Bennett, Graduate Student, Microbiology and Immunology Graduate Program
    Center for Genomic Sciences, Allegheny Singer Research Institute, Pittsburgh, PA
    Drexel University College of Medicine, Philadelphia, PA
    “Large-scale comparative genomics analysis provided for the characterization of a novel gene family in Haemophilus influenzae associated with invasiness”

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